Cleaning processing equipment (e.g. mixing vessels, pipelines) can cost personnel resources, cleaning chemicals, water and energy. Additionally, contamination from one chemical product to another is a concern. This presentation introduces the reader to state-of-the-art Clean-in-Place (CIP) technology which results in improved cleaning performance, reduced resource use, reduced cleaning time and more time for equipment to produce valuable products. The presentation also provides the reader with guidelines for designing and optimizing CIP facilities.